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Rglax Pharma

Process tool

Coating dispersion vessel and impeller sizing calculator

Vessel volume, diameter and impeller size for the dispersion quantity you are making.

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  • Working shownCheck every line by hand
  • Plant figuresThe bands our grades run in
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Written by the Rglax Pharma technical team, who formulate and manufacture every grade named on this calculator at our WHO-GMP works in Tahliwal, Una (drug manufacturing licence NNZ/23/238). Reviewed 3 September 2026. Licences and certificates.

A jacketed stainless mixing vessel with a top-mounted stirrer

Your batch

From the dispersion calculator

About 1.05 for a 15% aqueous dispersion

Headroom above the liquid, 20 to 30%

Result

Minimum vessel

12.3 L

Includes 25% freeboard

Liquid volume
9.8 L
Vessel diameter
250 mmAt a height to diameter ratio of 1
Liquid height
200 mm
Impeller diameter
83 mmOne third of vessel diameter
Impeller clearance
67 mmOff the base, one third of liquid height

How this was worked out

  1. liquid volume = 10.3 kg ÷ 1.05 = 9.8 L
  2. vessel = 9.8 L × (1 + 25 ÷ 100) = 12.3 L
  3. diameter = ∛(4 × 0.0123 m³ ÷ π) = 250 mm

Formula

vessel volume = liquid volume × (1 + freeboard ÷ 100)
D = ∛(4V ÷ π) at H/D = 1
impeller ≈ D ÷ 3, clearance ≈ liquid height ÷ 3

Why this number matters

A dispersion mixed in the wrong vessel never disperses properly. Too wide and the impeller cannot move the whole volume, so pigment settles at the wall. Too narrow and you draw a vortex that pulls air in, which reads as spitting at the gun and spray marks on the tablet. The one third rules for impeller size and clearance are the standard starting geometry.

Where it goes wrong

Freeboard is not optional. A ready-mix powder entrains air as it wets out and the level rises before it falls, so a vessel filled to the brim will foam over on the first minute of mixing.

Worked example

With dispersion weight of 10.3 kg, dispersion density of 1.05 kg/L and freeboard of 25 %, the calculation gives:

Liquid volume
9.8 L
Minimum vesselIncludes 25% freeboard
12.3 L
Vessel diameterAt a height to diameter ratio of 1
250 mm
Liquid height
200 mm
Impeller diameterOne third of vessel diameter
83 mm
Impeller clearanceOff the base, one third of liquid height
67 mm

The arithmetic is 3 lines, shown beside the result above so it can be checked by hand: vessel volume = liquid volume × (1 + freeboard ÷ 100); D = ∛(4V ÷ π) at H/D = 1; impeller ≈ D ÷ 3, clearance ≈ liquid height ÷ 3.

Typical ranges

  • Dispersion weight(kg)From the dispersion calculator
  • Dispersion density(kg/L)About 1.05 for a 15% aqueous dispersion
  • Freeboard(%)Headroom above the liquid, 20 to 30%

These are the bands our grades were developed in at Tahliwal. A run outside them is not wrong, but it is a run the published parameters no longer describe.

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Every grade page carries the process parameters it was developed on, so you can start from a known point rather than a calculated one. Browse the grades.

Need a second opinion

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Send the core, the coater and the target and we will tell you what we would run, and which grade we would run it with.

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