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Rglax Pharma

Process tool

Tablet surface area and coating build-up calculator

Surface area per tablet and coating build-up in mg per square centimetre, which is how enteric coats are specified.

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  • Plant figuresThe bands our grades run in
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Written by the Rglax Pharma technical team, who formulate and manufacture every grade named on this calculator at our WHO-GMP works in Tahliwal, Una (drug manufacturing licence NNZ/23/238). Reviewed 3 September 2026. Licences and certificates.

Steel calipers measuring the diameter of a coated tablet

Your batch

A 500 mg round tablet is usually 11 to 13 mm

Result

Surface area

4.335 cm²

Flat-faced approximation

Coating applied
40 mg per tablet
Build-up
9.23 mg/cm²

Inside the usual window of 4 to 12 mg/cm². Enteric coats usually target 6 to 10; below 4 gastro resistance is at risk and above 12 the film bridges the break line

Assessment
Typical enteric range

How this was worked out

  1. surface area = 2π(6)² + 2π(6)(5.5) = 4.335 cm²
  2. coating applied = 500 mg × 8% ÷ 100 = 40 mg
  3. build-up = 40 mg ÷ 4.335 cm² = 9.23 mg/cm²

Formula

surface area ≈ 2πr² + 2πrh
build-up (mg/cm²) = coating applied (mg) ÷ surface area (cm²)

Why this number matters

Percentage weight gain hides a real problem. A small tablet has far more surface area per unit weight than a large one, so the same percentage gain gives a much thinner film on the small tablet. Enteric coating is specified in mg per square centimetre for exactly this reason, and gastro resistance failures on small tablets almost always trace back to someone scaling on percentage instead.

Where it goes wrong

This uses a flat-faced approximation. A deeply concave or capsule shaped tablet has more surface area than the formula gives, so treat the result as a floor rather than an exact figure.

Worked example

With tablet diameter of 12 mm, tablet thickness of 5.5 mm, core weight of 500 mg and weight gain of 8 %, the calculation gives:

Surface areaFlat-faced approximation
4.335 cm²
Coating applied
40 mg per tablet
Build-up
9.23 mg/cm²
Assessment
Typical enteric range

The arithmetic is 2 lines, shown beside the result above so it can be checked by hand: surface area ≈ 2πr² + 2πrh; build-up (mg/cm²) = coating applied (mg) ÷ surface area (cm²).

Typical ranges

  • Tablet diameter(mm)A 500 mg round tablet is usually 11 to 13 mm

These are the bands our grades were developed in at Tahliwal. A run outside them is not wrong, but it is a run the published parameters no longer describe.

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Every grade page carries the process parameters it was developed on, so you can start from a known point rather than a calculated one. Browse the grades.

Need a second opinion

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Send the core, the coater and the target and we will tell you what we would run, and which grade we would run it with.

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