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Rglax Pharma

Coating defect

Dissolution failure after coating

An uncoated core that met specification falls outside it once coated, or disintegration time lengthens.

Written by the Rglax Pharma technical team, who formulate and manufacture every grade named on this guide at our WHO-GMP works in Tahliwal, Una (drug manufacturing licence NNZ/23/238). Reviewed 3 September 2026. Licences and certificates.

What usually sits behind it

  • Film build-up beyond what the release profile allows
  • A film chosen for appearance on a core where dissolution is the constraint
  • A core that was already marginal before the coat was applied

Every cause above is a process parameter, not a property of the material. If you are seeing dissolution failure after coating on a grade of ours, send us the run conditions and a retained sample and we will work back from them — start at the contact page.

A clear liquid in a shallow glass dish
Dissolution failure after coating, as it appears on a coated tablet. Illustration, not a photograph of production material.

Grades formulated against it

Where dissolution failure after coating is the problem the grade was made for

  • Extra white film coat for plain Amoxycillin

    Solvent base extra white film for plain Amoxycillin and dissolution critical tablets.

    Solvent base extra white film coat for plain Amoxycillin tablets and other products where dissolution has to be protected while the core is covered to a high opacity.

    Base ·
    Non-aqueous (solvent)
    Finish ·
    Extra white
    Formulated against ·
    Amoxycillin

  • Dissolution enhancer blend

    Corrects disintegration time and dissolution where the core falls short.

    Dissolution enhancer blend used as DT and dissolution material. It is added where a core formulation does not meet the specified disintegration time or dissolution profile and reformulating the core is not practical.

    Base ·
    Dry blend
    Finish ·
    Excipient blend

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